Von Willebrand Factor (VWF) and endogenous coagulation cascade components (VWF and coagulation factors)

Von Willebrand Factor (VWF) is a large multimeric glycoprotein essential for primary hemostasis, acting as a bridge between platelets and the vascular subendothelium at sites of injury (UniProt P04275; NIH MedlinePlus). It also serves as a critical carrier protein for Factor VIII (FVIII), protecting it from premature degradation in the bloodstream (UniProt P04275). The endogenous coagulation cascade consists of a series of serine proteases and cofactors—including Factors XII, XI, IX, VIII, X, V, and Prothrombin—that undergo sequential activation to ultimately generate thrombin and a stable fibrin clot (StatPearls, Physiology, Coagulation Cascade). Dysregulation of these components leads to either pathological bleeding, such as in Von Willebrand}

Other names

VWFCoagulation factorsClotting factorsHemostatic systemBlood coagulation cascade