Von Willebrand factor A domain-containing protein 3A (VWA3A)

Von Willebrand factor A domain-containing protein 3A (VWA3A) is a human protein coded by the VWA3A gene, found on chromosome 16. It contains a von Willebrand factor type A (vWA) domain, a structural motif commonly involved in cell adhesion, migration, and formation of multiprotein complexes. VWA3A is identified as a robust, disease- and age-independent marker of ependymal cells in the brain and spinal cord, shown to have a promoter that drives strong, specific transcription in ependyma across species. While associated diseases include intellectual developmental disorder and ataxia-telangiectasia-like disorder 2, VWA3A is not implicated as a drug target and currently has no characterized therapeutic relevance or interacting drugs. It is not considered a validated therapeutic target or receptor. No biomarkers or safety concerns have been established. Its main biological relevance is in cell type identity, specifically for ependymal cells, and its promoter's utility for achieving ependyma-specific gene expression in gene therapy vector design, particularly for neurological applications.

Other names

FLJ46765FLJ40941VWA3A

not applicable (no known drug targeting this protein)