Von Willebrand factor C domain containing 2 (VWC2)

Von Willebrand factor C domain containing 2 (VWC2) is a secreted protein primarily known as a bone morphogenetic protein antagonist, regulating BMP signaling in the extracellular space. It is involved in neural development, cell adhesion, and may play a role in bone formation and differentiation. VWC2 is part of a family of proteins containing the von Willebrand factor type C domain, which provides versatile binding characteristics for protein-protein interactions in development and pattern formation. Its function as a BMP antagonist positions it as a regulatory molecule rather than a classical receptor or enzyme, impacting growth factor signaling cascades relevant to skeletal and neural development.

Other names

VWC2BRORINVon Willebrand factor type C domain-containing protein 2HGNC:30200UniProtKB: Q2TAL6

BMP antagonist: inhibits signaling of bone morphogenetic proteins via competitive binding, particularly BMP-2 and BMP-6, affecting receptor interaction and downstream signaling. Modulation of extracellular signaling complexes affecting neural and bone development pathways.