Von Willebrand factor C domain containing 2 like (VWC2L)

Von Willebrand factor C domain containing 2 like (VWC2L) is a protein-coding gene located on chromosome 2 encoding an extracellular matrix-associated protein that may be involved in the development of nerve cells (neurogenesis) and the formation of bone (bone differentiation and matrix mineralization)[2][3][7][8]. VWC2L is predicted to be part of the AMPA glutamate receptor complex and to be localized in the extracellular region and synapse[3]. It is functionally related to the negative regulation of BMP signaling and the positive regulation of neuron differentiation[3][8]. Diseases associated with VWC2L include Tarsal-Carpal Coalition Syndrome and Sclerosteosis 1[3]. The protein is evolutionarily related to other von Willebrand factor C domain-containing proteins, which are involved in various aspects of cell adhesion, migration, homing, and signal transduction[1].

Other names

Von Willebrand factor C domain-containing protein 2-likeVWC2-like proteinBrorin-likebrorin-like