Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Von Willebrand Factor Fragment (VWF Fragment)
- Target
- VWF Fragment
- Molecular classification
- Glycoprotein, Coagulation factor, Protein fragment
01
Overview
Von Willebrand factor (VWF) fragments are proteolytically or recombinantly generated portions of the full-length VWF protein. They retain specific biological activities depending on which domains are present, such as mediating platelet adhesion, binding collagen, or stabilizing factor VIII. These fragments are clinically relevant in von Willebrand disease diagnosis and potentially as therapeutic agents.
- Other names
- VWF fragmentvon Willebrand factor domainVWF subunit
02
Mechanism of action
Mediate platelet adhesion via interaction with GPIbα, bind collagen or integrins depending on included domains, and/or stabilize circulating factor VIII if containing the D′D3 region.
03
Biological functions
Platelet adhesionCollagen bindingFactor VIII stabilizationHemostasis
04
Disease associations
Von Willebrand DiseaseThrombosisAtherosclerosisDiabetes mellitusSepsis
05
Safety considerations
Thrombogenicity of larger multimersImmunogenicity of recombinant fragmentsBleeding risk with excessive VWF inhibition
06
Interacting drugs
Heparin
3 more in the full profile.
07
Biomarkers
VWF antigenVWF activityVWF propeptideADAMTS13 activity
Beyond the preview
Go deeper on Von Willebrand Factor Fragment (VWF Fragment).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Von Willebrand Factor Fragment (VWF Fragment).