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von Willebrand factor pseudogene 1 (VWFP1)

Target: VWFP1
Molecular classification: Other (Pseudogene)

Overview

VWFP1 is a nonfunctional pseudogene located on chromosome 22 that duplicates the middle portion of the von Willebrand factor gene, spanning exons 23 to 34[1][2][3]. It is highly homologous (~97%) to the corresponding region of the VWF gene but does not encode a protein and is considered an evolutionary remnant. The existence of VWFP1 can complicate genetic analysis of VWF and von Willebrand disease due to gene conversion events, where sequences from VWFP1 may be introduced into the functional VWF gene, potentially contributing to genetic variation in VWF[1][3][4].

Other names: F8VWFLF8VWFPVWFPVWFP1

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