VPS10 domain-containing receptor SorCS1 (SORCS1)

VPS10 domain-containing receptor SorCS1 (SORCS1) is a type I transmembrane protein of the VPS10 domain receptor family, predominantly expressed in the central nervous system but also implicated in metabolic tissues[2][3][5]. SORCS1 regulates intracellular trafficking of membrane proteins, particularly critical for synaptic function and integrity. It sorts neuronal receptors such as neurexin 1α, influencing the balance between axonal and dendritic localization, thereby affecting neuronal connectivity and signaling[1][6]. Alternative splicing produces isoforms with distinct cytoplasmic tails, conferring varied trafficking and cell-surface expression[4][6]. SORCS1 interacts with proteins such as Rab11FIP5 (Rip11), SorL1, and Vps35, orchestrating endosomal sorting and recycling[1][6]. Beyond the brain, SORCS1 modulates metabolic pathways, with genetic variants linked to diabetes and systemic disease risk[2][6]. Its dysfunction or altered regulation is associated with Alzheimer’s disease (via effects on amyloid precursor protein), glycemic disorders, and some cancers—a basis for its consideration as a biomarker and potential therapeutic target[3][6][8].

Other names

Sortilin-related VPS10 domain-containing receptor 1SORCS1SorCS1hSorCSVPS10 domain receptor protein SORCS1VPS10 domain-containing receptor SorCS1

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