VPS13C divergent transcript (VPS13C-DT)

VPS13C divergent transcript (VPS13C-DT) is a non-coding RNA gene found adjacent to the VPS13C protein-coding gene. Divergent transcripts are generally transcribed in the opposite direction relative to an adjacent (often protein-coding) gene, forming a head-to-head sense/antisense gene pair. While protein-coding VPS13C plays a critical role in lipid transfer between the endoplasmic reticulum and late endosome/lysosome, participates in mitochondrial homeostasis, and is genetically linked to familial and sporadic Parkinson’s disease, the specific functions of VPS13C-DT are not well annotated. It is primarily referred to as an RNA transcript with no evidence of translation into a protein or direct involvement as a drug target, receptor, enzyme, transporter, or similar molecular class. As such, it does not fulfill criteria for a "target" for therapeutic intervention. The presence of "divergent transcript" in a gene name usually indicates a transcript of unknown or regulatory function rather than a protein-coding gene or established drug target. Key distinction: Do not confuse VPS13C-DT (a non-coding RNA) with intracellular lipid transporter VPS13C, which is a well-characterized protein involved in Parkinson’s disease and is under investigation as a disease-relevant protein target. No evidence in the literature describes VPS13C-DT as a direct therapeutic target, and its role, if any, in molecular pathology or as a biomarker remains undefined. If structured target information is required, use the protein "Vacuolar protein sorting 13 homolog C (VPS13C)", but not "VPS13C divergent transcript" or "VPS13C-DT" for therapeutic target purposes.

Other names

VPS13C-DTVPS13C divergent transcript