VPS35 pseudogene 1 (VPS35P1)

VPS35 pseudogene 1 (VPS35P1) is a genomic pseudogene related to the VPS35 gene, which encodes a core component of the retromer protein complex involved in endosomal protein sorting and implicated in several biological processes and human diseases. However, VPS35P1 itself is annotated as a pseudogene, which means it resembles the protein-coding gene VPS35 but is not believed to encode a functional protein. Pseudogenes typically arise from gene duplication or retrotransposition events and frequently accumulate mutations that inactivate their ability to express functional proteins. VPS35, the functional gene, is medically relevant (notably for neurodegenerative disease), but VPS35P1 has no documented biological activity, role in disease, nor is it a therapeutic target[1][2][3]. VPS35 pseudogene 1 (VPS35P1) is not a protein, enzyme, transporter, receptor, nor other functional molecular target. It is a non-coding DNA sequence with sequence similarity to the coding VPS35 gene but without known function in health or disease, nor druggability. Any reference to therapeutic targeting or disease relevance pertains to VPS35, not VPS35P1. There is no known error in the gene symbol or nomenclature, but this entry is not a bona fide target by standard pharmacological or molecular biology definitions. If you require information about the actual functional protein VPS35 (Vacuolar protein sorting-associated protein 35), please specify, as it is distinct from the pseudogene VPS35P1[1][2][3].

Other names

VPS35, retromer complex component pseudogene 1Vacuolar protein sorting 35 homolog pseudogene 1VPS35P1VPS35 pseudogene 1

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