VPS9 domain-containing protein 1 (VPS9D1)

VPS9 domain-containing protein 1 (VPS9D1) is a protein encoded by the VPS9D1 gene in humans. It is predicted to function as a guanine nucleotide exchange factor (GEF) for small GTPases and is likely involved in the regulation of endosomal trafficking and membrane dynamics, being active in the cytosol and endocytic vesicles[3]. VPS9D1 is orthologous to proteins across multiple species, with a highly conserved VPS9 domain that mediates its putative GEF activity. While the protein itself is not currently recognized as a direct therapeutic target or established disease biomarker, a neighboring and antisense long non-coding RNA (VPS9D1-AS1) is an emerging biomarker and functional contributor in several cancers, most notably colorectal adenocarcinoma, where it regulates tumor cell proliferation, migration, immune evasion, and gene expression via competing endogenous RNA pathways[2][4]. There are no known drug interactions or established mechanism-of-action data for the VPS9D1 protein itself. Key clarifications: - Most literature focuses on VPS9D1-AS1 (the lncRNA), not the protein VPS9D1; ensure to distinguish between these. - VPS9D1 is not currently known to be a validated direct drug target or commonly used biomarker. - Predicted functional roles derive from orthology and protein domain analysis, not in-depth biochemical characterization in humans. If you need structured information about the antisense RNA (VPS9D1-AS1), which *is* directly implicated in disease and being studied as a biomarker, please specify.

Other names

ATPBLC16orf7ATP-BLProtein ATP-BLVPS9 domain containing 1VPS9D1