WAC antisense RNA 1 (WAC-AS1)

WAC antisense RNA 1 (WAC-AS1) is a long non-coding RNA (lncRNA) transcribed antisense to the WAC gene at the chromosomal locus 10p12.1. It is part of a class of RNA molecules typically longer than 200 nucleotides that do not encode proteins but regulate gene expression and cellular functions. WAC-AS1 participates in multiple biological processes, especially in cancer, where it is implicated in regulation of tumor proliferation, progression, cell cycle, and glycolysis. It has context-dependent effects: acting as a protective factor in certain cancers (e.g., glioma) and a risk factor in others (e.g., hepatocellular carcinoma). WAC-AS1 also modulates immune cell infiltration and the tumor microenvironment, and plays a role in Hepatitis B virus replication by regulating autophagy pathways. While considered a biomarker for prognosis and disease characterization in some cancers, there is no evidence it is currently a direct target of any approved therapeutic agents

Other names

WAC Antisense RNA 1 (Head To Head)NONHSAG005482.2HSALNG0076905

Not directly targeted by drugs; acts as a functional regulator via competing endogenous RNA (ceRNA), influencing microRNAs (e.g., miR-320d, miR-192-5p) and modulating downstream gene expression in cancer and infection