Target intelligence / Profile preview

Waist circumference (WC)

Target
WC
01

Overview

Waist circumference refers to the distance around the abdomen at a specific anatomical point—typically midway between the lowest rib and the top of the hipbone, roughly in line with the belly button. It serves as an accessible indicator of central adiposity and visceral fat accumulation. Elevated waist circumference values are strongly associated with increased risk for type 2 diabetes, cardiovascular disease, hypertension, dyslipidemia, metabolic syndrome, and certain cancers—even among individuals whose body mass index falls within normal ranges. Measurement protocols vary slightly between organizations but generally involve using a flexible tape measure placed snugly around the bare abdomen after exhaling normally. While widely used in both clinical practice and epidemiological studies due to its simplicity and predictive value for adverse outcomes related to excess abdominal fat, waist circumference itself does not represent a molecular entity or druggable biological target.

Other names
Abdominal circumferenceWCwaist size
02

Biological functions

Indicator of central adipositySurrogate marker for visceral fatPredictor of cardiometabolic risk
03

Disease associations

Cardiovascular diseaseType 2 diabetesMetabolic syndromeHypertension/high blood pressureDyslipidemia/high cholesterol
04

Safety considerations

Improper measurement technique can lead to inaccurate assessment of health risks.Over-reliance on waist circumference alone may miss other important aspects of health status.Waist circumference should be interpreted alongside other measures such as BMI and overall clinical context.
05

Biomarkers

Used as a biomarker for abdominal obesity and related metabolic risk in clinical practice and research settings.Thresholds commonly used for men: >102 cm (>40 inches), sometimes >94 cm (>37 inches) depending on guidelines, indicating increased risk for metabolic diseases.Thresholds commonly used for women: >88 cm (>35 inches), sometimes >80 cm (>31.5 inches), indicating increased risk for metabolic diseases.

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