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Target intelligence / Profile preview
WAP four-disulfide core domain protein 10A (WFDC10A)
- Target
- WFDC10A
- Molecular classification
- Protease inhibitor (specifically serine-type endopeptidase inhibitor), Secreted protein, WAP-type four-disulfide core domain family
01
Overview
WAP four-disulfide core domain protein 10A (WFDC10A) is a small, secreted protein characterized by a signature motif containing eight cysteines that form four disulfide bonds, providing structural stability. Primarily acting as a serine protease inhibitor, WFDC10A belongs to a family involved in tissue protection, immunomodulation, and host defense. The exact biological functions and disease associations of WFDC10A are less defined than for several other WFDC members, but its molecular structure and gene localization suggest roles in the immune system and antiprotease-mediated regulation of inflammation.
- Other names
- WFDC10AWAP four-disulfide core domain protein 10AC20orf146WAP10dJ688G8.3putative protease inhibitor WAP10A
02
Mechanism of action
Inhibition of serine-type proteases; modulation of immune responses (based on family-wide function). Drug action mechanisms specific to WFDC10A are not established.
03
Biological functions
Protease inhibition (serine-type endopeptidase inhibitor)Immunomodulatory activityPossible antibacterial and antiviral functions (by analogy to other WFDC family members)
04
Disease associations
Cancer (some WFDC family members implicated in tumor suppression and prognosis)Inflammatory diseaseHeart failure (related WFDC proteins serve as biomarkers)Other (potentially infection, but WFDC10A-specific roles are less characterized)
05
Safety considerations
None reported specifically for WFDC10A. Therapeutic challenges for similar proteins include specificity and tissue distribution.
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