WASHC3 pseudogene 1 (WASHC3P1)

WASHC3 pseudogene 1 (abbreviated WASHC3P1) is annotated as a pseudogene—a genomic DNA sequence that resembles a protein-coding gene but is non-functional due to mutations such as frameshifts or premature stop codons[3][4]. In the context of the WASH gene family, only a subset—including WASHC1, also known as CCDC53—encodes a functional component of the WASH complex. WASHC3P1 does not produce a functional protein as it has disabling sequence defects (e.g., frameshifts, stop codons); it does not contribute to cellular processes, actin polymerization, or endosomal sorting, nor is it relevant to disease mechanisms or drug actions[3][4]. Most WASH protein family pseudogenes, including WASHC3P1, appeared in the human lineage after gene duplication and rapidly accumulated mutations, rendering them non-functional and precluding any therapeutic relevance[3][4]. Key clarification: - WASHC3P1 is a pseudogene, not a therapeutic target, and should not be confused with WASHC3/CCDC53 (a functional protein-coding gene and component of the WASH complex)[3][4]. - There is no evidence this pseudogene produces a protein or is involved in human disease or drug response; therefore, it is not appropriate for consideration as a target in biomedical research or drug development[3][4].

Other names

WASH3Ppredicted protein WASHC3 pseudogene 1