WASP family homolog 2, pseudogene (WASH2P)

WASH2P (WASP family homolog 2, pseudogene) is a non-protein-coding gene in humans, classified as a pseudogene due to the presence of disruptive mutations including premature stop codons, which prevent the formation of a functional protein[1][4]. Although it shares sequence similarity with WASP family proteins implicated in actin cytoskeleton regulation and intracellular trafficking, WASH2P does not produce a protein product and currently has no established physiological, disease, or therapeutic role[1][4]. Functional WASP family members—such as WASH1 (WASHC1)—are core components of the WASH complex, regulating Arp2/3-mediated actin polymerization and endosomal sorting, but WASH2P is not an active participant in these processes[2][3]. The gene is frequently misannotated as a potential target due to sequence similarity, but annotation efforts and proteomic data confirm that WASH2P does not contribute to the functional WASH complex in humans[2][4]. Note: WASH2P should not be selected as a drug target or biomarker, and confusion with protein-coding WASP family members (e.g., WASH1/WASHC1) must be avoided in research and drug development contexts.

Other names

WAS protein family homolog 2, pseudogeneWASH2PFAM39BMGC52000CXYorf1-like protein on chromosome 2Protein FAM39B

None applicable, as WASH2P does not encode a functional protein.