Water and extracellular matrix components

Water and extracellular matrix components refer to the non-cellular structural and fluid environment of tissues, most notably the ocular surface and the skin. In the context of pharmacology, these components serve as the primary therapeutic target for artificial tears, lubricants, and dermal fillers. Water provides the necessary hydration and osmotic balance, while extracellular matrix (ECM) components like mucins, glycosaminoglycans, and proteins provide structural integrity and lubrication. Drugs targeting these components, such as glycerin, polyethylene glycol, and hyaluronic acid, work by supplementing the natural fluid and matrix to alleviate conditions like dry eye syndrome and skin dehydration. These agents typically act through physical and osmotic mechanisms rather than binding to specific protein receptors. Additionally, emerging therapies like terahertz radiation are being explored for their ability to interact with water and ECM components to promote wound healing and tissue recovery.

Other names

Ocular surfaceTear filmExtracellular matrixWaterConnective tissue matrix

Lubrication, osmotic hydration, stabilization of the tear film, and supplementation of the extracellular matrix.