WD repeat, SAM and U-box domain-containing protein 1 (WDSUB1)

WD repeat, SAM and U-box domain-containing protein 1 (**WDSUB1**) is a protein-coding gene found in humans (chromosome 2) encoding a predicted enzyme involved in protein ubiquitination, functioning as a **ubiquitin-protein transferase**[2][5][12]. It contains characteristic domains including **WD40 repeats** (implicated in protein-protein interactions), a **sterile alpha motif (SAM) domain**, and a **U-box domain** (typically associated with E3 ubiquitin ligase activity)[1][10][12]. The biological function is primarily linked to **protein ubiquitination**, though detailed physiological or pathological roles remain poorly elucidated. Current data do not indicate established links to disease, use as a biomarker, or the existence of drugs targeting this gene, and it is not an established therapeutic target or recognized receptor, enzyme, or transporter[2][9][12].

Other names

WDSUB1WDSAM1UBOX6FLJ36175WD repeat, SAM and U-box domain-containing protein 1wdsub1