WD repeat and SOCS box-containing protein 2 (WSB2)

WD repeat and SOCS box-containing protein 2 (WSB2) is a member of the WD-protein subfamily characterized by five WD-repeats and a C-terminal SOCS box, allowing it to act as a substrate-recognition component of Elongin-Cullin-SOCS-box (ECS) E3 ubiquitin ligase complexes[1][3]. WSB2 mediates the ubiquitination and proteasomal degradation of proteins such as p53, promoting tumorigenesis through activation of the IGFBP3/AKT/mTOR pathway[2]. It regulates cytokine signaling as a negative modulator of IL-21 receptor-mediated STAT3 activation and modulates inflammatory responses by targeting lysine-methylated NF-κB subunits for degradation[1]. WSB2 is emerging as an oncogenic protein overexpressed in multiple tumor types and is a potential prognostic marker and indirect therapeutic target in cancer[1][2][3].

Other names

SBA2MGC10210CS box-containing WD proteinWD repeat and SOCS box containing 2WSB-2WSB2_HUMAN[1][3]

Ubiquitin-proteasome-mediated degradation of target proteins (notably p53); Indirect activation of IGFBP3/AKT/mTOR pathway by destabilizing p53; Regulation of cytokine receptor (IL-21R) signaling by reducing receptor expression and dampening STAT3 activation