WD repeat-containing protein 3 (WDR3)

WD repeat-containing protein 3 (WDR3) is a nuclear protein characterized by 10 WD repeats—structural motifs of approximately 30–40 amino acids ending in a tryptophan-aspartic acid (W-D) pair[1][3][4][5]. As a member of the WD repeat protein family, WDR3 acts as a scaffold or platform for protein-protein interactions in crucial complexes, particularly in the assembly of the small subunit (SSU) processome involved in ribosome biogenesis[1][3][4][5]. Its core cellular roles include rRNA processing, control of the cell cycle, and participation in functions such as signal transduction and gene regulation[1][3][4]. Although not a classic therapeutic target such as a receptor or enzyme, WDR3 has been described in cancer biology, where it integrates ribosomal biogenesis with the p53 pathway influencing cancer cell proliferation[7]. There are no known direct drugs, biomarkers, or established safety concerns for this molecule as a therapeutic target.

Other names

WD repeat domain 3WDR3FLJ12796UTP12DIP2dJ776P7.2WD repeat-containing protein 3-likeWD repeat domain 3 (wdr3)WD repeat domain 3 S homeolog (wdr3.S)AW546279D030020G18RikMGC76073sb:cb42wu:fb92b07