WD repeat-containing protein 35 (WDR35)

WD repeat-containing protein 35 (WDR35) is a core component of the intraflagellar transport A (IFT-A) complex, which is essential for the assembly and maintenance of primary cilia by mediating retrograde transport of proteins and membrane cargo from the ciliary tip to the base[1][3][4][6]. As a member of the WD repeat protein family, it facilitates multiprotein complex formation and has roles in cell cycle progression, apoptosis, and gene regulation[1][5][7]. WDR35 is crucial for proper Sonic Hedgehog signaling and developmental processes, especially during embryogenesis. Mutations in WDR35 disrupt ciliary function, manifesting as a spectrum of skeletal and multisystem ciliopathies, most notably cranioectodermal dysplasia (Sensenbrenner syndrome) and short-rib thoracic dysplasia[3][5]. No approved drugs specifically target WDR35; its dysfunction emerges primarily as a genetic disease mechanism rather than a current therapeutic target[1][5].

Other names

IFT121WD repeat domain 35KIAA1336MGC33196IFTA1FAP118CFAP118Intraflagellar transport protein 121 homologCED2SRTD7naofen