WD repeat-containing protein 36 (WDR36)

WD repeat-containing protein 36 is a member of the WD repeat protein family, characterized by WD repeat motifs that facilitate the assembly of multiprotein complexes[1][3]. WDR36 is a component of the small subunit processome, participating in the nucleolar processing of SSU 18S rRNA, which is essential for the formation of the small ribosomal subunit[3][9]. It is also involved in T-cell activation and is highly co-regulated with interleukin-2 (IL2)[9]. The protein is expressed ubiquitously, including in the nucleolus and cytoplasm[4]. Mutations in the WDR36 gene have been linked to adult-onset primary open-angle glaucoma and modulation of intraocular pressure[1][3]. While WDR36 is involved in key cellular processes such as cell cycle progression, apoptosis, and gene regulation, it is **not considered a typical therapeutic target** such as a receptor, enzyme, or transporter[1][3][9]. There are currently no known drugs that specifically target WDR36, nor established mechanisms of action, biomarkers, or notable therapeutic safety concerns related to this protein.

Other names

WD repeat domain 36WDR36UTP21GLC1GTA-WDRPT-cell activation WD repeat-containing proteinTAWDRPT-cell activation WD repeat protein