WD repeat-containing protein 48 (WDR48)

WD repeat-containing protein 48 (WDR48) is a scaffold protein characterized by multiple WD-repeat motifs forming a beta propeller structure. It primarily functions to regulate and activate deubiquitinase complexes, notably USP1, USP12, and USP46, by binding to these enzymes and facilitating their activity. WDR48 plays a central role in DNA repair through modulation of FANCD2 deubiquitination, and it promotes homologous recombination in conjunction with RAD51AP1. Through its regulatory actions, it is implicated in cancer biology (tumor suppression via PHLPP1 stabilization) and neurodegenerative disease (via genetic mutations). WDR48 is not known to be targeted directly by approved drugs, though it modulates pathways essential for genome stability and cell signaling.

Other names

USP1-associated factor 1UAF1KIAA1449p80SPG60Bun62WD repeat endosomal proteintesticular tissue protein Li 224

Activation of deubiquitinases such as USP1, USP12, USP46 by direct binding and inducing conformational changes to enhance enzyme activity; Stimulation of deubiquitination processes involved in DNA repair and signaling pathways