WD repeat-containing protein 62 (WDR62)

WD repeat-containing protein 62 (WDR62) is a large scaffold protein belonging to the WD-repeat family and is highly expressed in neural progenitors during embryonic development[1][3][4]. It localizes predominantly at spindle poles during mitosis, ensuring spindle formation, orientation, and dynamics, which is essential for neurogenesis and proper cerebral cortical development[5][6]. WDR62 acts as a scaffold within the JNK signaling pathway, regulating apoptosis, differentiation, and cell survival[3][4]. Mutations in WDR62 cause neurodevelopmental disorders, notably autosomal recessive primary microcephaly (MCPH) and other cortical malformations[1][5][6]. Aberrant expression has also been linked to tumor progression and chemoresistance in several cancer types[4]. In the male reproductive system, WDR62 is necessary for proper spermatogenesis[2]. The protein’s broad involvement in neurodevelopment and oncogenesis makes it a research target, though direct pharmacological modulators are lacking.

Other names

WDR62WD repeat domain 62C19orf14MCPH2DKFZP434J046FLJ33298

Potential mechanisms involve modulation of neurogenesis, mitotic spindle organization, and JNK pathway activity; however, these are theoretical as direct-targeting drugs are not available