WD repeat-containing protein 73 (WDR73)

WD repeat-containing protein 73 (WDR73) is a cytoplasmic and nuclear protein characterized by six WD40 repeats forming a six-bladed propeller structure, typically mediating protein-protein interactions. It acts as a scaffolding protein important for the assembly of the Integrator complex RNA endonuclease module by physically associating with members such as INTS9 and INTS11. WDR73 is essential for the regulation and organization of the microtubule network, ensuring proper cell cycle progression, cell survival, and possibly RNA processing and transcriptional control. Loss-of-function mutations in WDR73 cause Galloway-Mowat syndrome, a rare disorder involving both the central nervous system (especially cerebellar atrophy and microcephaly) and the kidney (nephrotic syndrome and focal segmental glomerulosclerosis), likely due to defects in cell survival and cytoskeletal organization in neurons and podocytes. WDR73 is not recognized as a classical therapeutic target (such as a receptor, enzyme, transporter, or ion channel), nor do known drugs directly target it.

Other names

Integrator complex assembly factor WDR73HSPC264FLJ14888FLJ00296 proteinGAMOS1GAMOSWD repeat domain 73