WD repeat-containing protein 82 (WDR82)

WD repeat-containing protein 82 (WDR82) is a nuclear scaffold protein with seven WD40 domains that acts primarily as a regulatory component of the SET1/COMPASS histone H3K4 methyltransferase complex, facilitating the recruitment of SETD1A or SETD1B to the phosphorylated C-terminal domain of RNA polymerase II at transcriptional start sites, enabling proper gene activation through H3K4 trimethylation[2][3][5]. WDR82 is also a component of the PNUTS-PP1 phosphatase complex, contributing to chromatin structure regulation and cell cycle progression[3][5]. It is essential for normal embryonic development, pluripotency maintenance, transcriptional regulation, and metabolic pathway modulation during somatic cell reprogramming[1][2][3]. Loss of WDR82 disrupts normal histone methylation and impairs proliferation and differentiation, and rare genetic defects in WDR82 are associated with specific neurodevelopmental and skeletal disorders[3][5]. There is no evidence to date that WDR82 is a direct target for therapeutic small molecules or biologic drugs.

Other names

SWD2TMEM113WDR82AMST107MSTP107PRO2730PRO34047hWDR82WDR82p