WD repeat-containing protein 91 (WDR91)

WD repeat-containing protein 91 (WDR91) is a WD40-repeat scaffold protein that functions as an essential effector of the small GTPase Rab7, playing a critical role in endosomal maturation by regulating the conversion between early and late endosomes[1][2][3][5]. It is specifically recruited to endosomal membranes through the interaction with active Rab7 and acts as a negative regulator of phosphatidylinositol 3-kinase (PI3K) activity, controlling levels of phosphatidylinositol 3-phosphate (PtdIns3P) to ensure proper endosomal maturation and trafficking[1][3][5]. WDR91 is a key part of the WDR81-WDR91 complex, which mediates efficient endolysosomal compartment fusion, thereby supporting the lysosomal degradation of surface receptors and endocytosed cargo[1]. Loss or dysfunction of WDR91 impairs endosomal transport and lysosomal degradation functions and is implicated in affecting neuronal development and associated with neurodegenerative phenotypes in genetic studies[1][5]. According to current data, WDR91 is not a direct therapeutic target, receptor, or enzyme, and there are no drugs or biomarkers currently known to interact with or act on WDR91[1][5].

Other names

SORF-1SORF1HSPC049