Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
WD repeat domain 1 (WDR1)
- Target
- WDR1
- Molecular classification
- WD-repeat protein, cytoskeletal regulatory protein, actin-binding protein
01
Overview
WD repeat domain 1 (WDR1) is a conserved actin-binding protein functioning as a critical co-factor for cofilin-mediated actin filament disassembly, facilitating essential cellular processes such as cytokinesis, migration, and cytoskeletal reorganization. WDR1 contains multiple WD repeats forming two β-propeller domains that serve as platforms for protein-protein interactions. Genetic deficiency or mutation of WDR1 results in lethality, immunodeficiency, epithelial defects, and has association with several cancers and developmental disorders. Because of its pivotal role in actin filament dynamics, WDR1 is under investigation as a potential therapeutic target for cancer and immunological diseases.
- Other names
- Actin-interacting protein 1AIP1WD repeat-containing protein 1NORI-1HEL-S-52PFITSepididymis secretory protein Li 52
02
Mechanism of action
Potential target for inhibition: limiting cancer cell migration and proliferation by suppressing actin filament turnover. Mechanism: disruption or modulation of cofilin-mediated actin filament disassembly.
03
Biological functions
Actin filament disassemblyCytoskeletal reorganizationCell migrationCytokinesisApicobasal and planar cell polarityEpithelial junction integrityImmune modulation
04
Disease associations
Cancer (including breast, glioblastoma, ovarian, thyroid)Immunodeficiency syndromesAutoinflammatory syndromesCongenital malformations (e.g., cleft palate)Metabolic disorders (e.g., potential risk factor for gout)
05
Safety considerations
Essential for cell viability; deficiency leads to lethality or severe tissue abnormalitiesPossible disruption of epithelial barrier function, leading to infection and inflammation riskImplicated in immune system dysfunction
06
Biomarkers
WD repeat domain 1 expression/upregulation as a cancer biomarker (breast, glioblastoma, ovarian, thyroid)WD repeat domain 1 mutations for primary immunodeficiency patient selection
Beyond the preview
Go deeper on WD repeat domain 1 (WDR1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on WD repeat domain 1 (WDR1).