WD repeat domain 13 (WDR13)

WD repeat domain 13 (*WDR13*) encodes a member of the WD repeat protein family, which is characterized by multiple WD repeat motifs, each approximately 40 amino acids long often ending with a tryptophan-aspartic acid pair[3][1][4]. WDR repeat proteins, including WDR13, adopt a beta propeller fold and serve as stable platforms for the assembly of multiprotein complexes, facilitating processes such as cell cycle progression, signal transduction, apoptosis, and gene regulation without intrinsic catalytic activity[1][4]. WDR13 is thought to negatively regulate pancreatic beta cell proliferation (based on mouse studies), with gene knockout resulting in increased pancreatic islet mass and higher serum insulin and mild obesity[3]. WD repeat domain proteins are involved in numerous cellular processes but are not typically considered direct drug targets due to the lack of enzymatic activity or classical ligand binding[4].

Other names

WD repeat-containing protein 13MG21WDR13

Not applicable; no drugs are known to specifically target WDR13. The protein acts primarily as a scaffold in multiprotein complexes.