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Target intelligence / Profile preview
WD repeat domain 47 (WDR47)
- Target
- WDR47
- Molecular classification
- Other (WD repeat-containing protein, cytoskeletal-associated protein)
01
Overview
WD repeat domain 47 (WDR47) is a cytoskeletal-associated protein containing multiple WD repeats, encoded by the human *WDR47* gene located on chromosome 1. It is predicted to play roles in neuronal stem cell maintenance, brain development (especially telencephalon), and sensory processes like thermal detection, primarily via associations with microtubules and protein complexes. WDR47 has been implicated in certain neurodevelopmental and neurodegenerative disorders. There is currently no evidence that WDR47 serves as a direct therapeutic target or that there are drugs in clinical use directly modulating its function.
- Other names
- WD repeat-containing protein 47KIAA0893Nemitinneuronal enriched MAP-interacting proteinnemitin
02
Biological functions
Neuronal stem cell population maintenancetelencephalon developmentdetection of hot stimulus involved in thermoceptionmicrotubule-associated functionprotein bindingmulticellular organism development
03
Disease associations
Neurodevelopmental disease (spinocerebellar ataxia, autosomal recessive 25; Marinesco-Sjogren syndrome)
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