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Target intelligence / Profile preview
WD repeat domain 59 (WDR59)
- Target
- WDR59
- Molecular classification
- Other (WD-repeat containing protein), Signaling adaptor (component of GATOR2 complex)
01
Overview
WD repeat domain 59 (WDR59) is a protein-coding gene and a component of the GATOR2 complex, which regulates the mTORC1 signaling pathway in response to amino acid availability. WDR59 acts as a signaling adaptor, enabling cellular responses to nutrient status and promoting cell growth via mTORC1 activation when amino acids are abundant. Functionally, WDR59 has tissue- and context-dependent roles, either promoting or inhibiting mTORC1 activity by modulating the interaction between the GATOR2 and GATOR1 complexes. Mutations or alterations in WDR59 have been implicated in diseases such as epilepsy and may contribute to tumorigenesis due to its role in mTOR signaling regulation
- Other names
- FLJ12270FP977KIAA1923MGC11230WD repeat-containing protein 59GATOR2 complex protein WDR59CDw12 antigenp90-120GATOR complex protein WDR59
02
Mechanism of action
Activation/inhibition of mTORC1 via modulation of GATOR2/GATOR1 complexes
03
Biological functions
mTORC1 signaling regulationcellular response to amino acid starvationcell growth regulation
04
Disease associations
CancerEpilepsy
05
Safety considerations
unknown
06
Interacting drugs
unknown
07
Biomarkers
unknown
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