WD repeat domain 70 (WDR70)

WD repeat domain 70 is a scaffold protein composed of six WD40 repeat domains that assemble into multiprotein complexes critical for DNA double-strand break repair. It functions as a subunit of the CRL4 complex and interacts with RNF20/40 E3 ligases to mediate monoubiquitylation of histone H2B, thereby enabling recruitment and transcription of major homology-directed repair genes such as BRCA1, BRCA2, and RAD51[2][1]. Loss or mutation of WDR70 impairs DNA repair, leading to genomic instability and increased susceptibility to carcinogenesis, especially in colorectal cancer[2]. There is growing interest in targeting WDR70 for therapeutic intervention in cancer, yet direct, clinically-approved drugs are not currently available[3].

Other names

WD40 repeat-containing protein 70WDR70

Drug targeting would likely act by: - Modulating protein-protein interactions within DNA repair or chromatin complexes - Affecting E3 ligase-mediated histone ubiquitylation - Altering transcriptional regulation of key DNA repair genes (BRCA1, BRCA2, RAD51)