WD repeat domain 88 (WDR88)

WD repeat domain 88 (WDR88) is a member of the WD repeat protein family, characterized by repeating WD (tryptophan-aspartate) motifs that form β-propeller structures and serve as scaffolding platforms for protein-protein interactions. WDR88 is widely expressed but its specific molecular functions remain poorly understood. Research suggests possible involvement in meiotic chromosome movement and nuclear envelope regulation, inferred from network studies and homology to functionally better-characterized WD repeat proteins. WDR88 has been identified as a candidate risk gene for schizophrenia due to support from rare variant association studies, but its role in other diseases is undefined. No drugs, biomarkers, or safety issues are currently linked to WDR88. Proteins with WD domains in general display broad biological functions, including regulation of gene expression, cell cycle, and chromatin dynamics; however, WDR88 itself has not yet been directly implicated beyond its potential neurological associations.

Other names

WD repeat-containing protein 88PQWDPQQ repeat and WD repeat-containing proteinWD repeat domain containing 88WD repeat domain 88

None known (no drugs or therapeutic inhibitors are described for WDR88 itself; mechanisms for other WD repeat proteins may involve inhibition of protein-protein interaction sites but this does not extend directly to WDR88)