WD repeat domain-containing protein 76 (WDR76)

WD repeat domain-containing protein 76 (WDR76) is a member of the WD40 repeat domain family, characterized by a multi-bladed beta-propeller structure enabling numerous protein-protein interactions. WDR76 plays a role in essential cellular processes such as DNA damage response and repair, apoptosis, cell cycle progression, and regulation of gene expression. It specifically binds 5-hydroxymethylcytosine, suggesting a function in epigenetic regulation. WDR76 has demonstrated significant involvement in the inhibition of tumorigenic RAS signaling in liver and colorectal cancer, making it an emerging candidate for targeted cancer therapy. Disease associations include cancer and congenital disorders of glycosylation. Research on direct therapeutic targeting and biomarker development for WDR76 is ongoing.

Other names

WD repeat domain 76WD repeat-containing protein 76WDR76FLJ12973Cmr1CDW14CMR1

Interacts with RAS proteins, leading to RAS protein destabilization and subsequent inhibition of tumor cell proliferation, transformation, and invasion. Acts as a potential epigenetic reader via specific binding to 5-hydroxymethylcytosine (5hmC).