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Target intelligence / Profile preview
WDFY3 antisense RNA 2 (WDFY3-AS2)
- Target
- WDFY3-AS2
- Molecular classification
- Long non-coding RNA, Antisense RNA, Other
01
Overview
WDFY3 antisense RNA 2 (WDFY3-AS2) is a long non-coding RNA (lncRNA) located antisense to the WDFY3 gene. It is not translated into a protein but appears to play roles in the regulation of WDFY3 gene expression. Reduced expression of WDFY3-AS2 has been associated with poor outcomes in some cancers such as breast cancer, where it is thought to act as a tumor suppressor. Its mechanism of action most likely involves post-transcriptional regulatory effects on WDFY3, though detailed functions are still being researched. There are no known direct drug interactions, mechanism-based therapies, or approved biomarkers based on this RNA, but ongoing research suggests potential relevance for cancer prognosis.
- Other names
- WDFY3-AS2WDFY3 antisense RNA 2 lncRNA
02
Biological functions
Regulation of gene expressionPotential tumor suppressor activityCorrelation with expression of WDFY3 gene
03
Disease associations
Cancer (e.g., breast cancer, where low expression may be associated with poor prognosis)Potential roles in neurodevelopmental disorders (only by association with WDFY3)
04
Biomarkers
Possible utility as a prognostic biomarker in breast cancer (expression levels correlate with disease outcome in some subtypes)
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