Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Wee one homolog (WEE1)
- Target
- WEE1
- Molecular classification
- Enzyme, Protein Kinase, Tyrosine Kinase, Serine-Threonine Kinase
01
Overview
WEE1 is a nuclear protein kinase that plays a crucial role in cell cycle regulation, specifically at the G2/M checkpoint. It inhibits CDK1/cyclin B complex activity by phosphorylating CDK1 at Tyr15, preventing premature entry into mitosis. WEE1 ensures proper DNA replication and repair before cell division. It is a therapeutic target in cancer, as inhibition can induce mitotic catastrophe, particularly in cells with compromised G1 checkpoints. It also has epigenetic functions.
- Other names
- Wee1 kinaseWEE1HuWEE1 protein kinase
02
Mechanism of action
Inhibition of WEE1 leads to premature mitotic entry and mitotic catastrophe, especially in cells with defective G1 checkpoint mechanisms.
03
Biological functions
Cell cycle controlG2/M checkpoint regulationDNA replication controlDNA repairEpigenetic regulation
04
Disease associations
Cancer
05
Safety considerations
Potential for off-target effects due to kinase family similarity.Toxicity associated with inducing mitotic catastrophe in normal cells.
Beyond the preview
Go deeper on Wee one homolog (WEE1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Wee one homolog (WEE1).