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Target intelligence / Profile preview
Serine/threonine-protein kinase WEE1 (WEE1)
- Target
- WEE1
- Molecular classification
- Enzyme, Protein Kinase, Serine/Threonine Kinase, Tyrosine Kinase
01
Overview
Serine/threonine-protein kinase WEE1 is a nuclear kinase that inhibits CDK1/cyclin B, preventing premature entry into mitosis. It plays a crucial role in the G2/M checkpoint, DNA damage response, and cell size control. WEE1 is a therapeutic target in cancer, with inhibitors designed to induce mitotic catastrophe in tumor cells.
- Other names
- WEE1 kinaseWEE1-like protein kinase
02
Mechanism of action
Inhibition of WEE1 prevents inhibitory phosphorylation of CDK1, leading to premature mitotic entry and mitotic catastrophe, particularly in cancer cells with defective G1 checkpoints. Selectivity against tumor cells due to reliance on G2/M checkpoint.
03
Biological functions
Cell cycle regulationG2/M checkpoint controlDNA damage responseCell size controlHistone modification
04
Disease associations
Cancer
05
Safety considerations
Potential for off-target effectsToxicity when combined with other chemotherapeutic agentsMitotic catastrophe can lead to complex cellular responses
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