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Target intelligence / Profile preview
Werner Syndrome ATP-dependent Helicase (WRN)
- Target
- WRN
- Molecular classification
- Enzyme, Helicase, RecQ-like DNA helicase, ATPase, Exonuclease
01
Overview
Werner syndrome ATP-dependent helicase (WRN) is a multifunctional enzyme crucial for maintaining genome stability. It functions as a DNA helicase and exonuclease, participating in DNA replication, repair, recombination, and telomere maintenance. Mutations in WRN cause Werner syndrome, a disorder characterized by premature aging and increased cancer risk. WRN is also a therapeutic target in certain cancers, particularly MSI-H tumors.
- Other names
- WRN proteinRecQ-like helicase WRNDNA helicase WRN
02
Mechanism of action
Loss or inhibition of WRN leads to cell death, especially in MSI-H tumors.
03
Biological functions
DNA replicationDNA repairHomologous recombinationExcision repairTelomere maintenanceGenome stabilityApoptosis modulation
04
Disease associations
Werner Syndrome (premature aging)Cancer predispositionGenomic instability
05
Safety considerations
Inhibition may have off-target effects due to WRN's role in essential DNA maintenance processes.Resistance mechanisms may emerge with long-term inhibition strategies.
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