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Werner syndrome helicase
- Molecular classification
- RecQ DNA helicase, Enzyme
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Overview
Werner syndrome helicase is an enzyme encoded by the WRN gene. It belongs to the RecQ family of DNA helicases and possesses both 3'-5' DNA helicase and 3'-5' exonuclease activities. The protein plays a critical role in maintaining genome stability by participating in various aspects of DNA metabolism, including replication, repair, recombination, transcription, and telomere maintenance. Mutations in the WRN gene cause Werner syndrome—an autosomal recessive disorder characterized by premature aging, increased cancer predisposition, and genomic instability.
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Mechanism of action
Inhibition of helicase activity
03
Biological functions
DNA replicationDNA repairDNA recombinationTranscriptionTelomere maintenanceGenome stability
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Disease associations
Werner SyndromeCancerPremature agingGenomic instability
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Safety considerations
Inhibition may cause DNA damagePotential for off-target effects
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