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Target intelligence / Profile preview
Werner Syndrome RecQ Helicase (WRN)
- Target
- WRN
- Molecular classification
- Enzyme, DNA Helicase, Exonuclease, Transcription factor
01
Overview
Werner syndrome RecQ helicase (WRN) is a nuclear protein with both ATP-dependent 3′→5′ DNA helicase and 3′→5′ exonuclease activities, essential for maintaining genome stability, telomere maintenance, and DNA repair. Mutations in WRN cause Werner syndrome, a premature aging disorder. WRN interacts with proteins involved in DNA replication, repair, and chromatin structure.
- Other names
- Werner syndrome proteinWRN protein
02
Mechanism of action
Helicase inhibition
03
Biological functions
Genome stabilityDNA replicationDNA repairTelomere maintenanceApoptosisChromatin structure maintenance
04
Disease associations
Werner syndromeCancerPremature agingGenomic instability
05
Safety considerations
Potential for off-target effects due to broad role in DNA metabolismDisruption of DNA repair pathwaysAccelerated cellular senescence
06
Interacting drugs
Werner Syndrome RecQ Helicase-IN-1
07
Biomarkers
WRN expression levelsTelomere lengthGenomic instability markersPromoter methylation
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