West Nile virus structural proteins (E protein (for envelope), C protein (for capsid); no unified abbreviation for both)

West Nile virus structural proteins include the envelope glycoprotein (E) and the capsid protein (C), which are essential for the assembly and infectivity of flaviviruses. The E protein is a class II fusion protein, undergoing conformational rearrangement to mediate virus-cell membrane fusion and viral entry; its structure features three domains and specialized pockets critical for these functions. The C protein forms α-helical homodimers, organizing the nucleocapsid and facilitating viral RNA packaging and assembly. Both proteins share conserved features with other flaviviruses but differ in key residues affecting host specificity and pathogenesis. Disruption of E or C protein function is a promising approach for antiviral drug and vaccine development. If you require structured metadata for a specific protein (E or C), it is recommended to refer to "West Nile virus envelope glycoprotein" or "West Nile virus capsid protein" rather than the ambiguous “structural proteins.”

Other names

West Nile virus E proteinWest Nile virus capsid proteinWNV envelope proteinWNV C protein

Inhibitors may block membrane fusion by binding the E protein’s hydrophobic pocket or prevent capsid assembly; Vaccines elicit neutralizing antibodies targeting E protein epitopes