Wheezing

Wheezing is a continuous, high-pitched whistling sound produced in the respiratory airways during breathing, typically most prominent during expiration (StatPearls, NBK442010). It is a clinical sign and physiological phenomenon rather than a molecular target, receptor, or enzyme. Wheezing occurs when air flows at high velocity through narrowed or obstructed intrathoracic airways, caused by factors such as bronchospasm, mucosal edema, or intraluminal secretions (Mayo Clinic; MedlinePlus). While wheezing itself cannot be targeted by a drug at the molecular level, it serves as a primary clinical indicator and endpoint for the effectiveness of therapies like beta-2 adrenergic agonists and inhaled corticosteroids (NIH, MedlinePlus). These drugs address the underlying molecular causes, such as smooth muscle contraction or inflammation, in conditions like asthma and COPD. Therefore, wheezing is categorized as a symptom used for diagnosis and monitoring therapeutic response rather than a druggable biological entity (PubMed, 11956555).

Other names

Sibilant rhonchiWhistling breathAirway whistlingNoisy breathing

Relief of wheezing is achieved through bronchodilation via beta-2 adrenergic receptor agonism or muscarinic receptor antagonism, and reduction of airway inflammation via corticosteroid-mediated gene regulation.