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Target intelligence / Profile preview
Widely Interspaced Zinc Finger Motifs protein (WIZ)
- Target
- WIZ
- Molecular classification
- Transcription factor, Zinc finger protein, Histone modification
01
Overview
WIZ (Widely Interspaced Zinc Finger Motifs) is a zinc finger protein that functions primarily as a transcriptional regulator. It is characterized by the presence of multiple C2H2-type zinc finger domains, which are unusually widely spaced. WIZ plays key roles in chromatin modification and gene expression regulation, mainly through its association with the G9a/GLP histone methyltransferase complex. It stabilizes the G9a/GLP heterodimer complex and mediates localization of this complex to DNA targets. WIZ participates in repression of fetal hemoglobin expression and is being explored therapeutically for sickle cell disease.
02
Mechanism of action
Targeted degradation of WIZ to reactivate HbF expression
03
Biological functions
Transcription regulationChromatin modificationRegulation of gene expressionHistone methyltransferase bindingTranscription corepressor binding
04
Disease associations
Neurodevelopmental disordersSickle cell diseaseAnxiety disorders
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