Target intelligence / Profile preview

Widely Interspaced Zinc Finger Protein (WIZ)

Target: WIZ
Molecular classification: Transcription factor, Zinc finger protein, Histone modification

Overview

WIZ (Widely Interspaced Zinc Finger protein) is a transcription factor characterized by multiple C2H2-type zinc finger motifs that are unusually widely spaced within the protein sequence. It plays a key role in chromatin regulation, gene repression, and epigenetic modification through its association with the G9a/GLP histone methyltransferase complex.

Mechanism of action

Recruitment of histone methyltransferases, transcriptional repression

Biological functions

Chromatin regulationGene repressionProtein stabilizationDNA bindingEpigenetic modification

Disease associations

Neurodevelopmental disordersHemoglobinopathies

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