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Target intelligence / Profile preview
Wilms tumor transcription factor (WT1)
- Target
- WT1
- Molecular classification
- Transcription factor
01
Overview
The Wilms tumor transcription factor (WT1) is a protein encoded by the WT1 gene, crucial for the development of the urogenital system. It functions as a tumor suppressor and can also act as an oncogene in certain contexts. WT1 regulates gene expression by binding to specific DNA sequences and plays roles in cell growth, differentiation, and apoptosis. It is associated with Wilms tumor, Denys-Drash syndrome, and other developmental disorders. In cancer, WT1 expression is used for disease monitoring and as a potential therapeutic target.
- Other names
- WT33Wilms tumor protein
02
Mechanism of action
WT1 acts as a transcription factor regulating gene expression critical for cell growth and differentiation. Targeting WT1 involves modulating its transcriptional activity to inhibit tumor growth.
03
Biological functions
Cell growth regulationdifferentiationapoptosismRNA metabolism or splicing
04
Disease associations
Cancer (Wilms tumor, acute myeloid leukemia, ovarian serous carcinomas)developmental disorders (Denys-Drash syndrome, Frasier syndrome)
05
Safety considerations
Overexpression of WT1 can lead to chemotherapy resistance in certain cancers.
06
Interacting drugs
Vaccines (targeting WT1)
1 more in the full profile.
07
Biomarkers
WT1 expression is used as a biomarker for monitoring hematological malignancies like acute myeloid leukemia.
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