Wnt-7b protein (WNT7B)

Wnt-7b protein is a member of the Wnt family of secreted signaling proteins fundamental in embryonic development, organogenesis, and tissue homeostasis. Wnt-7b is encoded by the WNT7B gene and functions primarily as a paracrine factor, activating the canonical Wnt/β-catenin signaling pathway upon binding to Frizzled and LRP5/6 receptors. In humans, Wnt-7b plays essential roles in the development of the placenta, lung, eye, kidney, dendrites, and bone. It is critical for establishing the cortico-medullary axis in kidney morphogenesis, and its absence results in severe developmental defects. Dysregulated Wnt-7b signaling is implicated in several cancers (gastric, pancreatic, esophageal) and is a promising therapeutic target in oncology and regenerative medicine. Expression and activity of Wnt-7b is used as a biomarker for certain diseases and tissue regeneration processes. Pharmacological targeting of the Wnt-7b and canonical pathway must be approached carefully due to its broad biological importance and risk of systemic toxicity.

Other names

Protein Wnt-7bWnt family member 7BWNT7B gene product

Inhibit Wnt secretion (e.g., PORCN inhibitors stop Wnt ligand production and signaling) Block Wnt ligand-receptor interaction (Frizzled/LRP5/6 antagonists) Modulate β-catenin stability and nuclear translocation (downstream Wnt pathway blockade)