Wnt family member 16 (WNT16)

Wnt family member 16 (WNT16) is a secreted signaling protein and member of the Wnt gene family, which consists of structurally related genes encoding proteins involved in oncogenesis, embryonic development, and tissue homeostasis[1][3][4]. WNT16 functions as a key ligand in canonical and non-canonical Wnt pathways, signaling primarily via Frizzled receptors. It plays an essential role in regulating bone mass and structure by inhibiting osteoclastogenesis and promoting osteoprotegerin production in osteoblasts, thus enhancing bone density and reducing fracture risk[4]. WNT16 dysregulation is implicated in skeletal diseases (osteoporosis, osteoarthritis), chemotherapy resistance in cancer, and skeletal developmental anomalies[1][4][2]. There are two main transcript variants of WNT16 with differential tissue expression, each likely driven by distinct promoters[3][4].

Other names

Protein Wnt-16wingless-type MMTV integration site family member 16wingless-type MMTV integration site family, member 16bWNT16B

Serves as a ligand for Frizzled receptors, activating the canonical Wnt/β-catenin signaling pathway to regulate cell proliferation, survival, and differentiation, especially in the context of bone and cancer biology[1][3][5].