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Target intelligence / Profile preview
WNT1-inducible signaling pathway protein 1 (WISP1)
- Target
- WISP1
- Molecular classification
- Matricellular protein, CCN family
01
Overview
WNT1-inducible signaling pathway protein 1 (WISP1), also known as CCN4, is a secreted matricellular protein and a member of the CCN family of extracellular matrix-associated signaling proteins. It regulates diverse cellular processes including cell adhesion, proliferation, differentiation, survival, motility, tissue repair, and wound healing. WISP1 plays a significant role in organ development, tissue regeneration, cytoprotection, and extracellular matrix production. It is implicated in various diseases including cancer, fibrosis, inflammation, and vascular disease.
- Other names
- CCN4
02
Mechanism of action
WISP1 interacts with multiligand receptors like integrins to regulate intracellular pathways including FAK, RAS/RAF/MEK/ERK, NF-κB, TGF-β, and PI3K/AKT.
03
Biological functions
Cell adhesionProliferationDifferentiationSurvivalMotilityTissue repairWound healingOrgan developmentTissue regenerationCytoprotectionExtracellular matrix productionOsteoblastic differentiationMesenchymal cell proliferation
04
Disease associations
Cancer progressionMetastasisFibrosisInflammationBone formationKidney diseaseAortic aneurysmLung injury
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