Wolbachia endosymbiont (null)

Wolbachia endosymbionts are intracellular Gram-negative bacteria of the Alphaproteobacteria, closely related to Anaplasma and Rickettsia[1][2]. They are maternally transmitted and infect an estimated 40–66% of insect species, as well as filarial nematodes of medical importance[1][5]. Wolbachia manipulate host reproduction to favor their own transmission, confer resistance to viral pathogens in insects, and are essential for nematode development and fertility[1][2][4][6]. In certain hosts, such as bedbugs, Wolbachia have evolved mutualistic roles by synthesizing vitamins[6]. Targeting Wolbachia with antibiotics is a successful strategy to treat filarial diseases and is being developed for vector-borne disease control[1][2].

Other names

WolbachiaWolbachia pipientisintracellular WolbachiaWolbachia bacterium

Inhibition of bacterial protein synthesis, causing depletion of intracellular Wolbachia. Disruption of nematode development and reproduction through loss of essential cellular functions in the host.