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Target intelligence / Profile preview
Wound and Keratinocyte Migration Associated Long Noncoding RNA 2 (WAKMAR2)
- Target
- WAKMAR2
- Molecular classification
- lncRNA
01
Overview
WAKMAR2 is a long non-coding RNA (lncRNA) that regulates skin wound healing by enhancing keratinocyte migration and restricting the production of inflammatory chemokines. Its expression is induced by TGF-beta signaling. WAKMAR2 binds c-Fos protein to regulate CLDN1 promoter activity, which is important for skin barrier function. It is downregulated in chronic wounds, and its deficiency impairs reepithelialization.
- Other names
- LOC100130476lnc-TNFAIP3
02
Mechanism of action
Binds c-Fos protein to regulate CLDN1 promoter activity.
03
Biological functions
Regulation of keratinocyte migrationRegulation of inflammationRegulation of wound healingRegulation of CLDN1 promoter activity
04
Disease associations
Chronic woundsSkin barrier disorders
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