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Target intelligence / Profile preview
Wound healing promotion via ABCB5-positive mesenchymal stromal cells (ABCB5+ MSCs)
- Target
- ABCB5+ MSCs
- Molecular classification
- Mesenchymal Stromal Cell, Stem Cell, ABCB5-expressing Cell
01
Overview
ABCB5-positive mesenchymal stromal cells (MSCs) are a subpopulation of skin-derived MSCs characterized by ABCB5 expression. They promote wound healing through immunomodulatory and anti-inflammatory mechanisms, including IL-1RA secretion and macrophage polarization, making them potential therapeutic agents for chronic wounds and RDEB.
- Other names
- Skin-derived ABCB5-positive mesenchymal stem cellsallo-APZ2-CVUAPZ2Skin-derived ABCB5+ dermal MSCs
02
Mechanism of action
Immunomodulation via IL-1RA secretion, macrophage polarization (M1 to M2 shift), suppression of TNF-alpha secretion
03
Biological functions
Wound healingImmunomodulationAnti-inflammationTissue regenerationMacrophage polarizationCell differentiationSelf-renewal
04
Disease associations
Chronic woundsVenous leg ulcersRecessive dystrophic epidermolysis bullosa (RDEB)
05
Safety considerations
Potential for tumorigenicity (though not indicated in studies so far)ImmunogenicityOff-target effectsDelivery method and biodistribution
06
Biomarkers
ABCB5 expression (cell surface marker)IL-1RA levelsM1/M2 macrophage ratio
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